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Vitamin B12 increased methylation levels of CpGs in regulatory regions of CCL3 The effects of COVID-19 and B12 on the methylation levels of the 21 CpGs located in the promoter region and proximal portion of the first exon of the CCL3 gene (GRCh38/hg38 chr17: 36,090,276 - 36,090,005) were evaluated by Bisulfite Sequencing PCR in an NGS platform from DNA libraries produced with aliquots of endpoints A and B from individuals representing MOD, SEV and CTRL groups
J Physiol Pharmacol 64: 597612
Further, many available clinical-based studies had incomplete or an absence of details of the medication or patient demographics including medications, medical and/or surgical history, and other notable findings such as GI symptoms
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