1st week on semaglutide First Weight Loss: What to Expect – PlexusDx First Week on Semaglutide GLP-1:

Talk to your healthcare provider about any existing medical conditions you have and share your concerns about not losing enough weight

Acidic pH impairs the activity of the mitochondrial L-2-HG removal enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) and enhances the protein stabilization of HIF-1, leading to its escape from the degradation pathway 90

Zinman et al., 2019

Titration then moves to 5mg, 7.5mg, 10mg, and potentially higher depending on tolerance and response

There are also more serious risks to consider, such as pancreatitis, gallbladder problems, kidney issues, thyroid tumors, and severe gastrointestinal conditions

Tammana TV, Sahasrabuddhe AA, Bajpai VK, Gupta CM (2010) ADF/cofilin-driven actin dynamics in early events of Leishmania cell division