Loren Pickart and colleagues isolated a short peptide from human plasma that extended the lifespan of cultured liver cells. They identified its sequenceglycyl-histidyl-lysine (GHK)and discovered that when bound to copper ions, it formed GHK-Cu, a complex with strong biological activity in cell growth and tissue repair
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Wang R, Hartman CA, Snieder H
Inflammopharmacology 7:114 Lovric-Bencic M, Sikiric P, Hanzevacki JS, Seiwerth S, Rogic D, Kusec V, Aralica G, Konjevoda P, Batelja L, Blagaic AB (2004) Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse
TB-500 is a synthetic version of a fragment related to thymosin beta-4
Fine lines show measurable reduction