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If a hypersensitivity reaction is suspected, discontinue Janumet, assess for other potential causes for the event, and institute alternative treatment for diabetes

DIRECTIONS FOR FUTURE RESEARCH The clinical use of GLP-1RAs and dual GIP/GLP-1RAs has risen sharply in recent years, driven by their proven efficacy in managing T2DM and obesity

50 Contrary to preclinical literature about the positive role of GLP-1 RAs on the rewarding and reinforcing behavior of drug abuse, the study in our review proposed that exenatide treatment did not help with euphoria and cocaine craving in the subjects

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These help extend satiety and blunt hunger in between meals

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