The authors compare multiple senolytic strategies including FOXO4-DRI, dasatinib plus quercetin, navitoclax, and fisetin, evaluating mechanisms of action, selectivity profiles, and safety considerations for each approach
References Gwyer, D., Wragg, N
While these side effects are relatively rare, they highlight the need for thorough clinical evaluations and monitoring
Georgios Panos Ran Li, 1 Zhengqin Ye, 1 Dunmin She, 2, 3 Ping Fang, 1 Guannan Zong, 1 Kerong Hu, 1 Dehong Kong, 1 Wei Xu, 1 Ling Li, 1 Yun Zhou, 1 Keqin Zhang, 1 Ying Xue 1 1 Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, Peoples Republic of China
Quality and purity vary significantly between suppliers
Studies in women with both obesity and PCOS show that GLP-1 medications can have positive effects on menstrual cycles, ovulation, and fertility