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The most typical example of predictive hepatotoxicity is the use of high doses of acetaminophen (APAP), which, along with aspirin, amiodarone, niacin, and methotrexate, are all direct liver damage caused by the drug itself or by its metabolites
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Heme oxygenase-1 prevents cardiac dysfunction in streptozotocin-diabetic mice by reducing inflammation, oxidative stress, apoptosis and enhancing autophagy
gastroenterology 31 (6), 637642
10.2337/dci18-0033 34 DavisJ.SinghS.SethiS.RoyS.MittraS.RayasamG.et al (2010)
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