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[15] Methionine donates methyl groups for the synthesis of S-adenosyl-methionine, which in turn drives phosphatidylcholine production and very-low-density lipoprotein assembly, facilitating export of triglycerides from hepatocytes and mitigating diet-induced steatosis
A study indicates that regular overdose of isolated vitamin B12 supplements, especially among male smokers, may increase the risk of lung cancer (Brasky et al., 2017)
Cyanocobalamin is generally considered safe in pregnancy
It raises IGF-1 levels (which can drive cell growth), can affect blood sugar regulation, and carries risks of promoting unwanted tissue proliferation
