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Large doses of folic acid given to an individual with an undiagnosed vitamin B 12 deficiency can correct megaloblastic anemia without correcting the underlying vitamin B 12 deficiency, leaving the individual at risk of developing irreversible neurologic damage (21)

Yet the consequences are unknown Bioavailability: there are four specific metabolic steps necessary to convert cyanocobalamin into one of the coenzyme forms, which is a clear metabolic disadvantage (3) Utilisation problems: certain hereditary diseases, as well as metabolic disorders, prevent the conversion of cyanocoalamin into the active B12 forms (4) Steals methyl groups: cyanocobalamin requires a methyl group to convert into methylcobalamin, which it takes from the important amino acid S-adenosylmethionine (SAM)

In the Abdulghani 1998 head-to-head trial, copper peptide outperformed both vitamin C and tretinoin for procollagen synthesis (70% vs

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