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Seven cardiovascular outcomes trials have been performed in the past 4 years, all of which found non-inferiority for cardiovascular outcomes, with many finding superiority of these drugs

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At 60 h-post injection, the mice were sacrificed and the biodistribution determined upon fluorescence imaging of the respective organs

Any disagreement was resolved by discussion with the senior author

Mechanistically, since SGLT2 is not expressed in cardiomyocytes, SGLT2 inhibitors exert their cardioprotective effects indirectly by targeting noncardiomyocytes, such as by inducing diuresis, modulating neurohormonal activation, and improving metabolism, rather than through direct actions on cardiomyocytes

Anti-Aging and Longevity Support As we age, GH and IGF-1 levels naturally decline