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RESULTS 3.1 Tirzepatide reduces body weight and improves glucose tolerance in HFD-fed mice Mice were subjected to high-fat diet (HFD) feeding with 12 weeks and followed with different drugs administration for 2 weeks, including vehicle, 10 nM [D-Ala2]-GIP, 10 nM semaglutide, 3 nM tirzepatide, and10 nM tirzepatide (Fig.1A)

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On average, clinical trials show that patients can lose 15-20% of their body weight during treatment

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