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The most significant results came from the in vivo animal studies
An early work, presented in 1995 by Dentico and colleagues, evaluated the effect of 30-day administration of high doses of intravenous or intramuscular GSH on liver cytolysis indexes in patients with chronic steatosic liver disease (77)
Oxidative stress occurs when there is an imbalance between free radicalsunstable molecules that can damage cellsand antioxidants
Because that figure comes from rodent research, many start patients at the low end (about 5 mcg/kg or a flat 250 mcg) and adjust over one to two weeks
Finally, in 2023, Wee et al
One phase II study did not find any substantial benefit of CoQ10 supplementation in patients with ALS (Kauffman 2009)
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