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Therapeutic Approaches to Enhance GLP-1 Activity Two pharmacological strategies are available to enhance GLP-1 signalling: DPP-4 Inhibitors Mechanism: Inhibit dipeptidyl peptidase-4 (DPP-4), the enzyme responsible for degrading endogenous GLP-1

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Direct costs for treating diabetes globally have been estimated to be around 860 billion USD per year, and 150 billion USD per year in the U.S

Twenty units equals 0.2 mL