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The effects of GLP-1 agonists on musculoskeletal health and orthopedic care

The triple receptor activation produces even more aggressive appetite suppression, which correlates with more pronounced gastric emptying delays

Oral GLP-1 therapies emerged as game-changers: Rybelsus (oral semaglutide) was approved for diabetes in 2019, and in December 2025 the FDA approved Wegovys first oral pill (25 mg semaglutide) for obesity ( [35] )

Given that retatrutide remains an investigational compound with no licensed indication in the UK, anyone considering its use or who has already used it should consult a qualified healthcare professional

Of note is that MTs have been effective in reversing many aspects of DCM, and the overexpression of MTs has efficiently reduced the degree of cardiac damage [23]

Michael Reisman is Association Director of Communications for River Crossing YMCA