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The preliminary data from observational studies like the NYU cohort and the Jorge outcomes study provide the justification for these trials, which will produce the higher-quality evidence needed for guideline recommendations

doi: 10.1016/j.ejphar.2020.173581 124 Barreto-ViannaARCAguilaMBMandarim-de-LacerdaCA

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These drugs are thought to work by engaging part of the brain called the hypothalamus, which helps regulate a wide variety of hormones, says Jena Shaw Tronieri, Senior Research Investigator at Penns Center for Weight and Eating Disorders and a co-author of the study