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While all patients lost weight, no significant improvement in liver fibrosis was observed

Rushing to higher doses significantly increases the risk of both local and systemic side effects

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Taken together the anti-cancer effect of biguanides is being studied in several types of cancer suggesting the potential repurpositioning not only of the anti-diabetics, but also of numerous other biguanides-related compounds

In some cases, this could result in rebound weight gain, especially if behavioral changes have not occurred alongside medication use

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