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FDA's own scientists recommended against it, citing inadequate physicochemical characterization, immunogenicity risk from aggregation and peptide-related impurities, and insufficient evidence of effectiveness

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Indeed, riboflavin suppresses the cortical neuronal endogenous release of glutamate via reduction in the activity of presynaptic voltage-gated calcium channels, inhibiting the exocytosis of glutamate vesicles (81)

2025 Feb 10;12(5):uhaf043