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Pregnancy is NOT a contraindication

Adding more diluent creates a less concentrated solution, while adding less diluent produces a more concentrated solution

Cohen himself tried to develop it as a drug, but the peptide was so unstable that it broke down within minutes

However, excessively concentrated solutions may cause irritation that paradoxically reduces absorption by triggering protective mucus secretion

The limited human research that does exist for these compounds offers inconclusive results

Abbreviations PREOG: Polyphenol rich extract of Ocimum gratissimum DAAM1: Disheveled-associated activator of morphogenesis 1 RSPH6A: Radial spoke head 6 homolog A PTMA: Prothymosin 3-HSD1: 3-Hydroxysteroid dehydrogenase type 1 17-HSD: 17-Hydroxysteroid dehydrogenase type 3 StAR: Steroidogenic acute regulatory protein PND: Postnatal day CdCL: Cadmium chloride GSI: Gonadosomatic index EPI: Epididymal index SOD: Superoxide dismutase GST: Glutathione S-transferase GPx: Glutathione peroxides MDA: Malondialdehyde H2O2: Hydrogen peroxide GSH: Glutathione q-RT-PCR: Quantitative real time polymerase chain reaction ROS: Reacting oxygen specie DNA: Deoxyribonucleic acid AR: Acrosome reaction OS: Oxidative stress FSH: Follicle stimulating hormone LH: Luteinizing hormone T: Testosterone GnRH: Gonadotropin realizing hormone References Sijo JP, Sandro CE, Ashok A