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In January 2026, the Pharmaceutical Benefits Advisory Committee (PBAC) issued a positive recommendation for Wegovy to be added to the PBS
But something unexpected happened during clinical use, something that caught researchers off guard and changed the conversation about hormonal health entirely
Therefore, weight gain is still possible if a healthy diet and regular exercise are not maintained
Use the pen exactly as directed by your doctor and do not share it with anyone
Heres what the research and my clinical experience reveal: Semaglutide is a well-established option with: Weekly injections Proven safety profile Average weight loss of 15-20% of body weight Effective appetite suppression Improvements in cardiovascular health markers Tirzepatide offers: Weekly injections Potentially greater weight loss (16-22.5% of body weight) Dual-action mechanism Similar side effect profile to semaglutide Enhanced metabolic benefits In a recent head-to-head trial , tirzepatide demonstrated superior weight loss compared to semaglutide, with participants losing an average of 20.2% versus 13.7% of their body weight at 72 weeks
doi:10.1523/JNEUROSCI.3262-11.2011 Volkow ND & Xu R (2025)
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