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Overall, the administration of charged NPs need to be performed avoiding potential side effects related to the used NP concentration (Zhang et al., 2021a): nanocarriers with superficial cationic motifs exhibit a higher macrophage uptake and clearance by the mononuclear phagocyte system (MPS) compared to uncharged nanosystems, reducing the internalization in the targeted cells

Enteroendocrine L cells sense LPS after gut barrier injury to enhance GLP-1 secretion

Biol Chem 376:651660

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Its -glutamyl bond to the cysteine residue provides unique chemical properties and high stability within the cell, allowing GSH to function as a powerful redox buffer

Alexis Granite, MD, is a board-certified dermatologist in America and England