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26 We observed that Con A injection weakly increased hydrogen peroxide and MDA level but GSH/GSSG ratio did not change by Con A injection in the liver of WT mice (Figure 6a)

These data demonstrate that high OxPhos signalling is associated with 5FU resistance and suggest that enhanced mitochondrial metabolism promotes treatment failure clinically

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10.1073/pnas.0900206106 25 MaughanS