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A comprehensive narrative review published in Biology synthesized 78 studies across five mechanistic domains and identified a compelling pathway
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Cardiometabolic improvements: Reductions in blood pressure, triglycerides, hepatic steatosis, and inflammatory markers across SURPASS and SURMOUNT trials
GI effects dominate: nausea (35-60%), diarrhea (20-40%), vomiting (~20%), and constipation (20-30%) at higher doses
Rapid weight loss, hormonal fluctuations, and caloric restriction all stress mood regulatory systems
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