Together, these findings suggest that circadian susceptibility in asthma may reflect impaired temporal coordination and intracellular competence of innate immune cells to execute melatonin-dependent redox buffering programs and identify the NRF2 glutathione axis as a therapeutically actionable pathway
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The agency would have to solicit public comment and an advisory committee of health and pharmacy experts would have to review the FDAs research
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2022 Kokot, Antonio et al