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Clinicians may prescribe it off-label to postmenopausal women

MCH1R antagonists have been shown to modulate leptin secretion and insulin release which suggests that the weight loss associated with systemic antagonist administration is due to both central and peripheral effects

Mannucci E, Mannucci DE

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Recently, in a phase 1 clinical study, AMG133 demonstrated a pronounced dose-dependent weight loss in participants with obesity