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The tolerable upper intake level set by the National Institutes of Health is 100 mg/day for adults, well above the therapeutic dose of 75 mg/day used in nausea trials (NIH Office of Dietary Supplements, Vitamin B6 Fact Sheet)
For GLP-1 medications like semaglutide and tirzepatide, cost is often the biggest barrier to starting treatment, or staying on it long enough to see results
Headaches and dizziness Headaches affect a meaningful percentage of users on both medications
Most cases improve after recovery
The key insight: slowed colonic motility is nearly universal on GLP-1 medications
How Much Weight Gain Is Typical After a Hysterectomy
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