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Even with semaglutide on board, elevated cortisol can counteract weight-loss efforts by shifting your body into a more conservative metabolic state
It disrupts the growth cycle, accelerates miniaturization, and can lead to permanent follicle death
Weight loss in week 1 is usually minimal (1-3 pounds, often water)
There is no absolute contraindication to using these medicines together, and no official pharmacological interaction has been documented that would prevent their concurrent use
PMCID: PMC8166598.
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