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10.1016/j.drudis.2016.06.004 20 GhoshC.HossainM.MishraS.KhanS.Gonzalez-MartinezJ.MarchiN.et al (2018)

Some add cyanocobalamin (B12)

Visible improvement may take 4-12 weeks, depending on the severity of pigmentation and consistency of use

References: Khavinson VKh

In one 2023 study involving over 2,400 people, about one in three participants lost at least 5% of their body weight over 72 weeks

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