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Cell Host & Microbe DOI:10.1016/j.chom.2026.05.003 Abstract Microbiota-driven gutbrain signaling underlies antidepressant effects of a GLP-1 analog Despite widespread clinical use of glucagon-like peptide-1 receptor (GLP-1R) agonists for metabolic disease, their neuropsychiatric effects remain poorly understood and controversial

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For people with rheumatoid arthritis (RA), lupus, psoriatic arthritis, or osteoarthritis, this chronic inflammation means more pain, swelling, stiffness, mobility problems, and tissue damage. Whats most shocking: unchecked inflammation is the root of many chronic diseasesRA, diabetes, gout, heart diseaseand doubles your risk of heart attack, stroke, and even premature death

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The fatigue lasted four days, not two weeks