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Research indicates that many addictive substances acutely increase dopamine signaling, although addiction also involves broader neurochemical, stress, learning, genetic, and environmental mechanisms

So for a research grade Melanotan II spray , the meaningful questions are whether the material is genuinely cyclized rather than linear precursor, whether the stereochemistry at the phenylalanine is correct, and whether an oxidized tryptophan species is present from poor storage

cancer.org.au Health Authorities Stance on Melanotan Leading health organisations have issued warnings against the use of unregulated Melanotan products: Cancer Council Australia: Advises against the use of tanning accelerators, including Melanotan, due to potential health risks and the lack of evidence supporting their safety

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The methyl group changes the original molecule into something different