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Tirzepatide and semaglutide shared similar rates for nausea, diarrhea, abdominal pain, and dyspepsia , but semaglutide had higher rates of vomiting, constipation, and GERD

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[63] Blood pressure and renal function should be monitored closely during dose escalation

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328 In one randomized clinical trial in women with severe IBS-D, alosetron was found to have significant beneficial effects versus placebo on numerous markers of quality of life (eg, emotional and mental health, sleep, energy, etc.) as well as workplace productivity