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Fertility of male or female rats was unaffected by metformin when administered at doses as high as 600 mg/kg/day, which is approximately 3-times the maximum recommended human dose based on body surface area comparisons
Injecting outside approved sites or into areas with poor subcutaneous tissue, active skin conditions, or scar tissue may compromise medication delivery and increase infection risk
Hyperoxalemia leads to oxidative stress in endothelial cells and mice with chronic kidney disease
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