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A dermatology review flagged that there are essentially no adequate studies of intravenous glutathione for skin lightening, and that its safety for repeated IV use has not been established (a dermatology review concluding that IV glutathione for skin lightening has inadequate safety data)

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Interestingly, when FOXO4 expression was silenced in TM3 cells using siRNA prior to H2O2 treatment, cell viability decreased, and apoptosis increased, despite elevated p53 levels