Introduction# CagriSema (cagrilintide + semaglutide, Novo Nordisk) and tirzepatide (Eli Lilly) represent the pinnacle of next-generation obesity pharmacotherapy, both achieving approximately 20% weight loss through different dual-mechanism approaches
The combination addresses appetite, food reward, gastric emptying, and insulin sensitivity through a broader receptor engagement than GLP-1 agonism alone
The actual transition timeline should be individualized based on your response to both medications, your weight loss trajectory, and your side effect profile
We have seen patients with burns, permanent discoloration and scarring of their skin from laser procedures, she continued, flagging serious risks for filler injections, including side effects like blood vessel blockages that can lead to permanent scarring and blindness
Even if you've always maintained a healthy BMI, midlife has a way of changing the game
In the earliest iterations, monolayer endothelial cells alone (BBB-on-chip) or with astrocytes and pericytes (NVU-on-chip) were cultured as in transwell systems (Jiang et al., 2019)