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Refrigerated at 28 C, used within approximately four weeks, and protected from repeated freezethaw cycles

SURMOUNT-1 (72-week randomized study, adults without diabetes): tirzepatide produced an average loss of 15.0% (5 mg dose), 19.5% (10 mg dose), and 20.9% (15 mg dose) of body weight, versus 3.1% with placebo, under a similar lifestyle-intervention protocol

Serum B12 reference ranges vary between laboratories, but generally, levels below 148 pmol/L are considered deficient, whilst levels between 148258 pmol/L are regarded as borderline and may warrant further investigation or a trial of treatment, particularly if symptoms are present

Arenas J, Huertas R, Campos Y, Diaz AE, Villalon JM, Vilas E

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This effect means food and fluids remain in the stomach longer, which can influence both appetite and fluid intake patterns