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doi:10 } : CS1 maint: multiple names: authors list (link) "Scientific conclusions and grounds for the variation to the terms of the marketing authorisation(s)" (PDF) (data sheet)

GLP-1 receptor agonists like semaglutide stimulate beta cells in the pancreas to release insulin in response to meals and slow gastric emptying

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The disadvantages center on three issues: testicular suppression and infertility, polycythemia risk (the overproduction of red blood cells that raises blood viscosity and thrombotic risk), and the requirement for ongoing exogenous administration with no exit strategy that preserves hormone function