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Retatrutide has a higher overall adverse event burden (6-10% discontinuation), partly because of the unique dysesthesia side effect at higher doses

An important role is to inactivate incretins (GLP-1 & GIP)

Springer, US, New York, NY, pp 2127 Hiller F, Besselt K, Deubel S et al (2015) GPx2 induction is mediated through STAT transcription factors during acute colitis

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or by rectal surgery