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In a 72-week trial in adults with obesity without diabetes, the mean percentage change in weight was -15.0% (5 mg), -19.5% (10 mg), and -20.9% (15 mg) vs -3.1% with placebo

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Maske et al., 2018

These drugs were originally designed to help people with type 2 diabetes manage their blood sugar, but a surprising side effect turned out to be weight loss

Certain peptides stimulate growth hormone release, which can influence the Pituitary gland

At the maintenance dose of 2.4 mg per week, Wegovy costs between $350 and $500 per month in Australia when prescribed privately