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1,2 Tirzepatide carries a boxed warning stating that the medication causes thyroid C-cell tumors in rats

Tirzepatide has shown stronger efficacy for NAFLD/NASH than any prior GLP-1 monotherapy, and the data comes from head-to-head trials, not indirect comparisons

2656383-23-0 Chemical Name: Tirzepatide intermediate P10 Synonyms Tirzepatide intermediate P10;(S)-N-((S)-1-Amino-3-(tert-butoxy)-1-oxopropan-2-yl)-1-(O-(tert-butyl)-N-(O-(tert-butyl)-N-glycyl-L-prolyl-L-seryl)-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl)pyrrolidine-2-carboxamide, 2,2,2-trifluoroacetate salt CBNumber: CB212810550 Molecular Formula: C48H81N11O13.C2HF3O2 Molecular Weight: 1134.25 MDL Number: MOL File: 2656383-23-0.mol MSDS File: SDS Last updated:2026-05-27 23:55:13 Tirzepatide intermediate P10 Preparation Products And Raw materials Raw materials Preparation Products Tirzepatide intermediate P10 (S)-N-((S)-1-Amino-3-(tert-butoxy)-1-oxopropan-2-yl)-1-(O-(tert-butyl)-N-(O-(tert-butyl)-N-glycyl-L-prolyl-L-seryl)-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl)pyrrolidine-2-carboxamide, 2,2,2-trifluoroacetate salt 2656383-23-0 C50H82F3N11O15

They bypassed insurers and PBMs, capturing ~5x the margin of branded Wegovy ( source )