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308 Historically, a natural menopausal transition has been recognized as a life stage marked by gradually decreasing levels of estradiol (E2, the predominant ovarian estrogen) and progesterone accompanied by increasing levels of FSH and LH, beginning in earnest about two years before and stabilizing about two years after the last menstrual period

So physicians really need to do their homework and avoid prescribing for high-risk patients, Lyddy said

Its important to talk to your healthcare provider about your options and to consider the potential benefits and risks of each medication