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Additionally, Parasutterella relative abundance, which was increased in both the vehicle- and NNMTi-treated LD-switched groups relative to the controls, significantly correlated with several adipose tissue metabolites abundances

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MRI may show cerebral white matter atrophy, ventricular enlargement, periventricular gliosis, optic nerve atrophy, delayed myelin formation or dysplasia, cerebellar hypoplasia, cerebellar hemisphere atrophy, and hypersignal in the subcortical white matter [116, 117]

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