semaglutide new england journal of medicine (Wegovy) first weight management medication in the world to show reduction in cardiovascular events soul study semaglutide New data

This allows 0.1ml for 1mg doses or 0.2ml for 2mg doses, volumes easily measured with insulin syringes

doi: 10.1038/s43016-024-01095-7, 124 RheaE

Tumor-targeted glutathione oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma

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These results suggested that GLP-1 expression was gradually decreased in CM, and also revealed that although the protein expression of GLP-1R was upregulated after NTG stimulation, the amount of GLP-1Rs that can be activated was decreased, so the activity of GLP-1R in the TNC in CM model was actually inhibited

For non-diabetic users the question is whether both are needed: tirzepatide is far stronger for weight loss at 5 mg and above, while metformin is cheaper, oral, and more modest