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[169] In January 2024, a preliminary review conducted by the US Food and Drug Administration (FDA) confirmed no evidence had been found to suggest that the medicine causes suicidal thoughts or actions
The mutation of GLP-1 Phe 28 to Ala causes it to lose nearly all of its affinity (IC 50 : 0.27 nM357 nM), and Ile 29 mutation decreases the affinity notably (IC 50 : 0.27 nM25 nM), while Trp 31 , Leu 32 , and Val 33 mutations have little influence, showing that they may be merely subsidiary
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Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M et al (2017 Jan) ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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