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4.4 Mechanistic exploration of repurposed anti-diabetic drugs Preclinical data reporting the neuroprotective effects of drugs such as GLP-1 receptor agonists (e.g., Liraglutide) and SGLT2 inhibitors raise the possibility that their benefits extend beyond glycemic control to potentially encompass the inhibition of ferroptosis (Ma et al., 2025)

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At the same time, important questions remain, particularly regarding long-term use in larger and more diverse patient populations

The salt form does not change what the peptide does once it reaches target tissues

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Still, to pave the way for more widespread clinical applications of gut-based interventions, future research will need to shift emphasis on more reward phases and clinical populations, ideally using larger samples with publication of the associations regardless of their threshold as full maps and regardless of a potential confirmation or rejection of the hypothesized action on reward responses