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It acts as a dual-acting agent, combining the properties of a uricosuric and a nonsteroidal anti-inflammatory drug (NSAID)

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Funding This study was funded by Isfahan University of Medical Sciences

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doi: 10.3389/fnins.2021.630016 Received 16 November 2020 Accepted 20 January 2021 Published 05 February 2021 Volume 15 - 2021 Edited by Matthew William Pitts, University of Hawaii at Mnoa, United States Reviewed by Frederick P

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and Sato (134, 135) observed an increase in 3-nitrotyrosine levels (a product of tyrosine nitration) in severe allergic reactions

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Thermal-shift assay Thermal-shift assay was performed as described previously 55

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