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Blanpied TA, Clarke RJ, Johnson JW

In short, a lower price is helpful, but safety still comes first

Some researchers report stable results up to 45 or 60 days, but 28 days is the window within which potency is most reliably maintained

These are the most efficacious medications that I have seen in my clinical practice in almost five decades, said Michael Camilleri, a gastroenterologist studying gastrointestinal diseases and obesity at the Mayo Clinic

Clinical trials show both semaglutide and tirzepatide have favorable safety profiles when used as directed, with nausea and gastrointestinal effects being most common, occurring in roughly 25-40% of users

Patients with a history of gastrointestinal conditions such as acid reflux, irritable bowel syndrome, or gastroparesis should be especially cautious when starting GLP-1 medications