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[42] The EFSA also reviewed the safety question and reached the same conclusion as in the United Statesthat there was not sufficient evidence to set a UL for vitamin B 12

While animal studies show a good safety profile, a theoretical risk involving its pro-angiogenic effects and potential cancer promotion is a point of consideration, though no evidence has supported this risk in practice

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While they likely have many types of anti-aging and performance-enhancing therapies available to them, some health-conscious celebrities choose B-12 when they want to optimize their metabolism to stay thin, trim, and vibrant

End-stage renal disease or severe hepatic impairment requires caution

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