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doi: 10.1002/oby.70155
Endocrinology, Diabetes & Metabolism, 6 (3)
These numbers come from separate clinical trial programs and should not be used as a direct head-to-head comparison
Some users report insomnia and even feeling unusually cold when doses are too high too fast
Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]
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