According to NICE guidance (NG28), the continuation of GLP-1 receptor agonist therapy in type 2 diabetes should be assessed after six months, with treatment continued only if there is a reduction in HbA1c of at least 11 mmol/mol (1%) and, where applicable, a weight loss of at least 3% of initial body weight
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A Review of practical issues on the use of glucagon-like peptide-1 receptor agonists for the management of type 2 diabetes
The two agents indicated for weight loss are semaglutide (a GLP-1 analog) and tirzepatide (an analog of glucose-dependent insulinotropic polypeptide [GIP] that activates both GIP and GLP-1 receptors)
Fontaine KR, Redden DT, Wang C, Westfall AO, Allison DB
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