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Timing Matters: The Interplay between Early Mealtime, Circadian Rhythms, Gene Expression, Circadian Hormones, and Metabolism-A Narrative Review

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As toxicologic pathologists sometimes experience difficulties in distinguishing the wide variety of liver lesions in the rodents for safety evaluation purposes, this document is a consensus of senior toxicologic pathologists regarding suggested nomenclature that should be used for specific lesions

This raises significant patient safety concerns

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Part of this migratory effect can be attributed to the stimulation of IL-1 secretion by resident macrophages via MSU crystals, which subsequently instigates caspase-11 expression in macrophages through IL-1R and MYD88 (55)