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Beginning with a lower dose allows the body to adjust to changes affecting appetite and digestion

The predicted binding pose revealed that the compound establishes stabilizing interactions with a set of hydrophobic and aromatic residues lining the transmembrane binding cavity (Figure 4), including A200, L201, M204, L217, Y220, V229, and W297

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This suggests that the observed quantitative differences may be related to the transition from the maternal to zygotic genome