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Concluding remarks Together, the role of GLP-1 RAs has expanded beyond glycemic control in T2D, becoming a cornerstone in obesity management

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conducted a magnetic resonance imaging (MRI) study and found that long-term chronic hyperglycemia can mediate hippocampal dysfunction, 19 and hyperglycemia inflammatory mediators, rheological factors, and dysregulation of the hypothalamicpituitaryadrenal axis also may exacerbate cognitive decline

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doi: 10.1016/j.ejps.2012.10.006 130 BowersCYAlsterDKFrentzJM